CIBOR’s Biocompatibility Core provides testing to determine both toxic and stimulatory outcomes in a variety of in vitro and in vivo settings. Typical evaluations include:

• In vitro cellular adaptation using fibroblastic, macrophage, and osteoblastic cell lines
• In vitro cellular responses in cell populations from specific patient populations
• Determination of inflammatory reactions using cellular and cytokine based responses
• Short-term in vivo biocompatibility testing to establish reactivity using the established murine air pouch model
• Long-term in vivo biocompatibility testing to establish compatibility with respect to bioengineering concepts (compression, interface strength, structural failure) and biological outcomes of tissue biocompatibility and osteointegration